Taxonomy, Phylogeny, and Biochemical Function of Venomous Marine Snails

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Screen Shot 2016-04-21 at 3.53.37 PMVerdes, A.; Anand, P.; Gorson, J.; Jannetti, S.; Kelly, P.; Leffler, A.; Simpson, D.; Ramrattan, G.; Holford, M. From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins. Toxins20168, 117

Screen Shot 2016-03-21 at 1.04.10 PMMoon J, Gorson J, Wright M, Yee L, Khawaja S, Shin Hye, Karma Y, Musunri R, Yun M, Holford M. Characterization and Recombinant Expression of Terebrid Venom Peptide from Terebra Guttata. Toxins , 2016 8.3:63

Screen Shot 2015-12-11 at 1.52.39 PMFry B, Koludarov I, Jackson T, Holford M, Terrat Y, Casewell N, Unheim E, Vetter I, Ali Sm Low D, Sunagar K. Seeing the Woods for the Trees: Understanding Venom Evolution as a Guide for Biodiversity. Royal Society of Chemistry, 2015 1-36

Screen Shot 2015-12-11 at 2.03.43 PMKelly P, Anand P, Uvaydov A, Chakravartula S, Sherpa C, Pires E, O’Neil A, Douglas T, Holford M. Developing a Dissociative Nanocontainer for Peptide Drug     Delivery. International Journal of Environmental Research and Public Health, 2015 12:10

Screen Shot 2015-12-11 at 1.43.04 PMAnand P, O’Neil A, Lin E, Douglas T, Holford M. Tailored delivery of Analgesic Ziconotide Across a Blood Brain Model Using Nano Containers. Nature Scientific Reports, 2015 5:12497

shapeimage_4-2Gorson J, Ramrattan G, Verdes A, Wright ME, Kantor Y, Srinivasan R, Musunuri R, Packer D, Albano G, Qiu WG, Holford M. Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails. Gen. Biol. Evol, 2015 7(6):1761-1778. doi: 10.1093/gbe/evv10

droppedImage_2-3Modica MV, Puillandre N, Castelin M, Zhang M, Holford M. A Good Compromose: Rapid and Robust Species Proxies for Inventorying Biodiversity Hotspots Using the Terebridae (Gastropoda: Conoidea), PLoS ONE, 2014 9(7): e102160. doi: 10.1371/journal.pone.0102160

droppedImage_1-4Anand P, Grigoryan A, Bhuiyan MH, Ueberheide B, Russell V, Quinonez, J, Moy, P, Chait, B, Poget, S, Holford, M. Sample Limited Characterization of a Novel Disulfide-Rich Venom Peptide Toxin from Terebrid Marine Snail Terebra Variegata. PLoS ONE, 2014 9(4): e94122. doi: 10.1371/journal.pone.0094122

shapeimage_3Puillandre N, Modica MV, Zhang Y, Sirovich L, Boisselier MC, Cruad C, Holford M, Samadi S. Large-scale Species Delimitation Method for Hyperdiverse Groups. Molecular Ecology, 2012 Jun 21(11): 2671-2691. doi: 10.1111/j.1365-294X.2012.05559.x

1-s2.0-S1055790312000966-fx1Castelin M, Puillandre N, Kantor YI, Modica MV, Terryn Y, Cruaud C, Bouchet P, Holford M. Macroevolution of Venom Apparatus in Auger Snails (Gastropoda; Conoidea; Terebridae). Molecular Phylogeneticc and Evolution, 2012 Jul 64(1): 21-44.

Ppic5uillandre N, and Holford M, The Terebridae and Teretoxins: Combining Phylogeny and Anatomy for the Concerted Discovery of Bioactive Compounds. Chemical Biology, 2010 10:7

pic7Modica MV, and Holford M. The Neogastropoda: Evolutionary Innovations of Predatory Marine Snails with Remarkable Pharmacological Potential. in P. Pontarotti (ed), Evolutionary Biology – Concepts, Molecular and Morphological Evolution, 2010 doi: 10.1007/978-3-642-12340-5_15

Hoholford2lford M, Auer S, Laqua M, Ibanez-Tallon I. Manipulating Neuronal Circuits with Endogenous and Recombinant Cell-surface Tethered Modulators. Frontiers in Neuroscience. 2009 2:1-10. doi: 10.3389/neuro.02.021.2009

Holpic2ford M, Puillande N, Modica MV, Watkins M, Collins R, Bermingham E, Olivera BM. Correlating Molecular Phylogeny with Venom Apparatus Occurence in Panamic Auger Snails (Terebridae). PLoS ONE. 2009 4(11): e7667

pic1Holford M, Puillandre N, Terryn Y, Cruaud C, Olivera BM, Bouchet P. Evolution of the Toxoglossa Venom Apparatus as Inferred by Molecular Phylogeny of the Terebridae. Molecular Biology and Evolution, 2009 26(1): 15-25. doi: 10.1093/molbev/msn211

pic3Holford M, Zhang M, Catlin P, Azam L, Hanuman K, Green G, Watkins BR, Oqnby M, Yoshikami JP, Bulaj G, Oluvera BM. Prunning Nature: Biodiversity-Delivered Discovery of Novel Sodium Channel-Blocking Conotoxin from Conus bullatus. Toxicon 2009 53:90-98

Ksomethingholer F, Holfors M, Van Tuo D, Thanh HH. Exploring a Largely Unknown Fauna: On the Diversity ofPachychilid Freshwater Gastropods in Vietnam (Caenogastropoda: Cerithioidea). Molluscan Research, 2009 29(3): 121-146

Tvisaya0001erryn Y, and Holford M. The Terebridae of the Vanuatu Archipelago with a Revision of theGenus Granuliterebra Oyama 1961. The Desctiption of a New Genus and a Three New Species. Visaya, 2008 December Supplement 3

Holford Laboratory at CUNY Hunter College